Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy
Glaysher, S; Gabriel, FG; Johnson, P; Polak, M; Knight, LA; Parker, K; Poole, M; Narayanan, A; Cree, IA; NHS Collaborative Research Programme for Predictive Oncology
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Ovarian cancer shows considerable heterogeneity in its sensitivity to chemotherapy both clinically and in vitro. This study tested the hypothesis that the molecular basis of this difference lies within the known resistance mechanisms inherent to these patients' tumours.