Biotin-kodecytes - novel function-spacer-lipid (FSL) modified cells capable of being recovered from the circulation after 3 days

Abstract

The ability to modify a population of blood cells with both an antigen of interest and an identification-recovery label, infuse them into the circulation of an animal, and then visualize or recover a sample of the infused cells some hours-days later for analysis, is now possible through the use of FSL (function-spacer-lipid) constructs. FSL constructs are analogous in structure to a flower and consist of three components; a functional head group (like the flower head), a pacer (like a stalk) and a diacylipid tail (the anchoring roots). All FSLs are biocompatible and allow users to introduce novel functional moieties to the membrane surface of living cells.